Contrave Weight-Loss Medication
Contrave combines naltrexone and bupropion in an extended-release tablet. Its contraindications and drug interactions differ from GLP-1 medications and stimulant appetite suppressants.
Who needs particular caution
W8MD reviews blood pressure, seizure risk, eating-disorder history, alcohol or sedative withdrawal, bipolar symptoms, liver or kidney issues and all opioid use. Naltrexone can block opioid pain medicine and can precipitate withdrawal in a person dependent on opioids.
How W8MD chooses a medication
Medical fit
Conditions, medications, contraindications, interactions, prior response and monitoring needs.
Patient fit
Injection or tablet preference, eating pattern, schedule, side-effect priorities and treatment goals.
Practical fit
Insurance formulary, authorization, availability, pharmacy access and sustainable total cost.
Safety and follow-up
Contrave is contraindicated with uncontrolled hypertension, seizure disorders, certain eating disorders, other bupropion products, chronic opioid use, abrupt withdrawal from certain substances, monoamine oxidase inhibitors within the prohibited interval and pregnancy. Bupropion-containing products carry important neuropsychiatric and suicidality warnings.
Follow-up evaluates response, tolerance, nutrition, hydration, bowel symptoms, blood pressure or laboratory information when relevant, activity, lean-mass goals and maintenance planning. Dose escalation is not automatic.
Related resources: Medical weight loss · Medication guide · GLP-1 comparison · Affordability · Costs and insurance · Anti-obesity medication encyclopedia
For current product labeling and safety information, consult Drugs@FDA.
Ask W8MD which option fits you
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Medical and pricing notice: General education only, not medical advice. Evaluation is required and a prescription is not guaranteed. Eligibility, product, dose, pharmacy, availability, insurance coverage, total price and results vary. Seek urgent care for severe symptoms and call 911 for an emergency.
Content reviewed for general accuracy by W8MD clinical leadership. Last reviewed September 2026.
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