Medication evidence and regulatory status

Emerging and Investigational Weight-Loss Medications

Obesity drug development is moving quickly, but promising trial results do not make a medicine FDA-approved, commercially available or appropriate for routine prescribing.

Approved medicationsAppointments

Research and emerging weight loss medications

Current FDA status: This medicine or topic includes investigational treatment. Retatrutide, CagriSema, MariTide and aleniglipron are not FDA-approved for routine prescribing as of September 4, 2026. W8MD does not offer products sold online as “research peptides.”

Current status overview

Retatrutide

Investigational triple-receptor agonist in phase 3 studies.

CagriSema

Investigational cagrilintide/semaglutide combination studied in phase 3.

MariTide

Investigational antibody-peptide conjugate in a phase 3 program.

Aleniglipron

Investigational oral small-molecule GLP-1 agonist in clinical trials.

Foundayo

FDA-approved oral orforglipron—not an investigational drug.

How W8MD can help now

Patients do not need to wait for a future drug to receive evidence-based care. W8MD can compare currently approved weight-loss medications, nutrition, sleep treatment and non-medication plans using medical history, prior attempts, preferences, coverage and sustainable cost.

Discuss currently available options with W8MD

Brooklyn: 718-946-5500 · Northeast Philadelphia: 215-676-2334

Use the form only for a non-urgent callback request. Do not submit private medical, insurance, financial or other sensitive information.


    For appointments and important matters, please call the appropriate W8MD office:


    Philadelphia:
    215-676-2334

    Brooklyn / New York City:
    718-946-5500


    Do not use this form for emergencies or urgent medical concerns.
    Call 911 or go to the nearest emergency department for an emergency.


    This form is only for non-urgent appointment and general service requests.
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    Fields marked with an asterisk are required. Appointment availability,
    services and treatment eligibility vary. A medical evaluation is required
    before treatment or prescribing.

    Medical and research notice: Educational information only. Trial status and regulatory status can change. The first W8MD visit is in person. No drug, trial enrollment, prescription, coverage, availability or outcome is guaranteed. Call 911 for an emergency.

    Status reviewed September 4, 2026. Recheck FDA labeling and ClinicalTrials.gov before relying on this page.

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