Saxenda(liraglutide) joins the list of 4 new weight loss drugs approved by the US FDA since June of 2012 – Belviq(Lorcasering) and Qsymia(Phentermine and Topiramate) in 2012, and Contrave and Saxenda in 2014

How does Saxenda for weight loss work?
Saxenda(liraglutide) is a selective glucagon-like peptide-1 (GLP-1) receptor agonist type medication that was approved in December of 2014 in addition to diet and exercise for weight loss in those who are obese with a body mass index of 27 or more with a comborbid condition or those with a BMI of over 30. A lower dose of the same medication was approved in January 2010 as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM) (tradename: Victoza). The maximum approved dose for the diabetes indication as Victoza is 1.8 mg daily, administered as a subcutaneous injection while the weight loss dose was 3.0 mg administered similarly.

How effective is Saxenda for weight loss?

In one clinical trial assessing the effectiveness and safety of Saxenda, patients had an average weight loss of 4.5 percent from baseline compared to treatment with a placebo (inactive pill) at one year. In this trial, 62 percent of patients treated with Saxenda lost at least 5 percent of their body weight compared with 34 percent of patients treated with placebo.

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